Sertoli cell tumour in a neonate calf: an unusual congenital tumour. A case report.

Congenital testicular tumours are seldom reported in bovine species. This case report describes the clinical, sonographical, haematological, pathomorphological and immunohistological features of a Sertoli cell tumour in a neonatal German Holstein calf. Microscopically, the enlarged testicle was composed of neoplastic cells, which were packed in well-formed tubules. The mostly polygonal shaped cells had round to elongated nuclei and a scanty eosinophilic cytoplasm. Some cells were arranged perpendicularly to the light PAS-positive basement membrane. These cells were packed in broad sheets separated by dense fibrous stroma. Mitotic figures were present. The features described above are indicative of a Sertoli cell tumour. The contralateral testicle showed a well formed rete testis, fusiform cells and a dense central capillary convolute and haemorrhagic foci. The features are indicative of an extensive fibrosis and older haemorrhage. The neoplasia was immunopositive for vimentin, α-oestrogen receptor, α-inhibin and S-100 protein, but immunonegative for cytokeratine, CD30, progesterone receptor, α-fetoprotein, SALL4, OCT4 and glypican-3. The mycotoxicological investigations revealed the presence of residues of zearalenone, deoxynivalenol, ochratoxin, HT2 toxin and their metabolites in feeds and urine of heavily pregnant cows of the herd. Furthermore, information is provided about oestrogen and testosterone levels of the affected and healthy neonatal calves. A possible influence of mycotoxins on the cancerogenesis is discussed.

Neoplasias testiculares en caninos: un caso de tumor de células de sertoli / Testicular neoplasms in dogs: a case of sertoli cell tumor

Las neoplasias del testículo no son muy frecuentes en los animales domésticos Los caninos son los que las manifiestan con mayor frecuencia; estando entre los 0.7 y 4.6% de todos los tumores que sufren. Algunos factores se han asociado como predisponentes: entre ellos la edad madura y la presencia del criptorquidia uni o principalmente bilateral. Las neoplasias del testículo más frecuente son el tumor de células de Sertoli, el tumor de células de Leydig y los seminomas, que en general presentan la conducta benigna. El tratamiento recomendado previa evaluación clínica, es la orquiectomía (uni o bilateral), incluidos en los casos de criptorquidismo el testículo alojado en el escroto. En el presente manuscrito se realiza una revisión del tema en su primera parte; en la segunda, se describe el caso de un tumor de células del Sertoli en un canino Cocker que presentó al examen clínico un testículo retenido y síndrome feminizante. En este se caso se efectuó el diagnóstico histopatológico después de la extracción quirúrgica de la masa abdominal y también se realizó la extirpación del testículo alojado en el escroto.

Clinical behavior and a contemporary management algorithm for prepubertal testis tumors: a summary of the Prepubertal Testis Tumor Registry.

PURPOSE: The Prepubertal Testis Tumor Registry was established by the Urologic Section of the American Academy of Pediatrics in 1980 to record data on a large number of prepubertal testis tumors regarding presentation, treatment and outcome to define appropriate management better. We reviewed the registry data in the context of other modern studies to elucidate the appropriate management of these rare tumors. MATERIALS AND METHODS: Relevant data in the prepubertal testis tumor registry were tabulated and analyzed. RESULTS: There were 395 prepubertal patients who had a primary testis tumor. Generally benign tumors accounted for 38% of cases. A significant proportion of tumors were benign regardless of patient age. alpha-Fetoprotein levels for patients with benign and malignant tumors overlapped in children younger than 6 months. Of the patients with yolk sac tumor 80% presented with stage 1 disease and overall survival was excellent. There were no metastases or deaths among the patients with teratoma. Of all patients with stromal tumors metastases developed in only 1. CONCLUSIONS: We recommend initial excisional biopsy for all amenable prepubertal testis tumors, except those with an alpha-fetoprotein level that is clearly increased for patient age. Patients with benign tumors may be released from oncological followup. Patients with stage I yolk sac tumor should be monitored closely, and those with recurrent or metastatic yolk sac tumor should be treated with chemotherapy. Retroperitoneal lymph node dissection is reserved for patients with recurrent retroperitoneal masses following chemotherapy. Aggressive treatment of metastatic Sertoli cell or undifferentiated stromal tumors is warranted.